Scientists at Harvard University have developed a way to vastly accelerate single-cell sequencing, an advance that promises to give a major lift to biomedical genomics research.
The new approach combines microfluidics and novel software to accelerate single-cell ATAC-seq, which identifies parts of the genome that are open and accessible to regulatory proteins. Detailed in a June 24 article in Nature Biotechnology, the innovation was the product of a collaboration between Harvard’s Department of Stem Cell and Regenerative Biology (HSCRB) and researchers at Bio-Rad Laboratories.
“We’ve scaled it up so we can profile many cells in a human tissue in a straightforward way. The method is simple, so you can run the experiment in a day, start to finish. That will allow researchers to achieve much more in a far shorter time,” said Jason Buenrostro, senior author on the study and an assistant professor in HSCRB.
For many years, scientists have been trying